Retinal nerve fibre layer attenuation: clinical indicator for vigabatrin toxicity

Peripapillary retinal nerve fibre layer thickness in individuals with epilepsy exposed to vigabatrin

Retinal nerve fibre layer polarimetry: histological and clinical comparison.

AIMS To compare histological thickness of the retinal nerve fibre layer in the primate with retardation measurements obtained in vivo using the Mark II Nerve Fiber Analyzer (NFA, Laser Diagnostic Technologies, San Diego, USA). METHODS Scanning laser polarimetry was performed on both eyes of a healthy anaesthetised adult primate (Macaca mulatta). The retinal nerve fibre layer thickness was mea...

Detecting vigabatrin toxicity by imaging of the retinal nerve fiber layer.

PURPOSE To quantify retinal nerve fiber layer thickness (RNFLT) and macular thickness (MT) in patients exhibiting vigabatrin-attributed visual field loss (VAVFL) and to determine the efficacy of these measures as markers of the retinal damage associated with vigabatrin. METHODS This was a prospective cross-sectional observational study involving five groups: Group I, 13 patients exhibiting VA...

Retinal nerve fibre layer thickness in ARSACS: myelination or hypertrophy?

Autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS) was first described in the French-Canadian founder population of Quebec in 1978, but genetically confirmed patients have now been reported in individuals from Europe and Japan. Ataxia, dysarthria, spasticity with extensor plantar reflexes, distal muscle wasting, sensorimotor neuropathy and horizontal gaze-evoked nystagmus consti...

Retinal Nerve Fibre Layer Thinning in Alzheimer Disease